THE ROLE OF GUT
MICROBIOTA IN IMMUNE HOMEOSTASIS
Manole COJOCARU[1],
Gheorghe GIURGIU[2]
Abstract.
The
microbiota plays a fundamental role in the induction, education, and function
of the host immune system. The gut microbiota has such profound effects on
both the innate and adaptive immune system. Both environmental factors as
well as host genetics influence the composition and homeostasis of
gastrointestinal tract microbiome.
Objectives Understanding the
interaction of gut microbes with the host immune system is a timely and
important health topic. The purpose of this systemic review was to collect and analyse current data of the association between gut
microbiota, immune homeostasis, and Imuniplant in the
management of disfunctional immune responses.
Materials and methods In this presentation we will focus our discussion on the
exploration of the homeostatic relationship between the host immune system and
the microbiota. Imuniplant modulation of the immune
system has applications within the clinical setting, but can also have a role
in healthy populations, acting to reduce or delay the onset of immune-mediated
chronic diseases.
Results Alterations of these
gut microbial communities can cause immune dysregulation, leading to autoimmune
disorders. Imuniplant may restore the composition of
the gut microbiome and introduce beneficial functions to gut microbial
communities, resulting in amelioration or prevention of gut inflammation and
other intestinal or systemic disease phenotypes, possibly also as a genetic
modulator (CARD14 gene).
Conclusion This presentation
describes how Imuniplant and intestinal luminal
conversion by gut microbes play a role in immune-mediated chronic diseases.
Ongoing research in this field will ultimately lead to a better understanding
of the role of diet and Imuniplant from Deniplant in immune function.
Keywords:
gut microbiota, dysbiosis, immune homeostasis, Imuniplant
DOI https://doi.org/10.56082/annalsarscibio.2022.2.94
